New Agents for the Treatment of Acute Lymphoblastic Leukemia

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It binds to CD20, a protein that is found on the surface of healthy B cells and on the lymphoblastic B cells of approximately one half of adults with B-cell ALL. When rituximab binds to CD20, it signals the cell to die. Rituximab is not used alone to treat ALL, but it is added to a chemotherapy regimen. Some studies have shown that the addition of rituximab to standard chemotherapy improved survival among adults with CDpostive ALL.

Side effects may include infections, chills, fatigue, body aches and low blood cell counts. In some cases, the leukemia cells do not have CD19 on the surface. Such cells can evade tisagenlecleucel and multiply. A research goal is to find other markers on leukemia cells that can be targeted along with the CD19, such as CD For information about the drugs listed on this page, visit Drug Listings.

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Live Chat. J Clin Oncol s, suppl; abstr National Cancer Institute. December 14, ; Accessed: June 20, Smith M, Goodman B. August 30, ; Accessed: August 30, FDA approval brings first gene therapy to the United States. August 30, ; Accessed: June 20, Kymriah tisagenlecleucel [package insert].

CANCER RESEARCH Catalyst

August, Granulocyte colony-stimulating factor as an adjunct to induction chemotherapy for adult acute lymphoblastic leukemia--a randomized phase-III study. A randomized controlled trial of filgrastim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study Granulocyte colony-stimulating factor G-CSF, filgrastim after or during an intensive remission induction therapy for adult acute lymphoblastic leukaemia: effects, role of patient pretreatment characteristics, and costs.

Intensive short term therapy with granulocyte-macrophage-colony stimulating factor support, similar to therapy for acute myeloblastic leukemia, does not improve overall results for adults with acute lymphoblastic leukemia. Efficacy of granulocyte and granulocyte-macrophage colony-stimulating factors in the induction treatment of adult acute lymphoblastic leukemia: a multicenter randomized study.

Hematol J. Control of plasma uric acid in adults at risk for tumor Lysis syndrome: efficacy and safety of rasburicase alone and rasburicase followed by allopurinol compared with allopurinol alone--results of a multicenter phase III study. Arch Pathol Lab Med. Ann Oncol. The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukemia: update of the evidence-based review. Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses.

Short course high dose mitoxantrone with high dose cytarabine is effective therapy for adult lymphoblastic leukemia. Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. Pulmonary arterial hypertension in patients treated by dasatinib. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias.

Clinical Trials | Leukemia and Lymphoma Society

Ponatinib in refractory Philadelphia chromosome-positive leukemias. Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia MLL -rearranged acute lymphoblastic leukemia: results from the Interfant Study. Treatment of adults with acute lymphoblastic leukaemia in first bone marrow relapse: results of the ALL R protocol. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia.

Phase I study of U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission. Long-term outcome of a pediatric-inspired regimen used for adults aged years with newly diagnosed acute lymphoblastic leukemia. Specialty: Multispecialty.

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Array of Leukemia Clinical Trials Provides New Options for Patients

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  4. FDA Approves New Acute Lymphoblastic Leukemia Treatment | Cancer Network.
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Yes No. Related Questions:. Media Gallery. This website also contains material copyrighted by 3rd parties. Medscape Consult. View More. Need a Curbside Consult? Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL. Iclusig ponatinib [package insert].

Cambridge, MA. December Available at [Full Text]. Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A propensity score analysis. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols?

Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Am J Hematol.


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    Mulcahy N. Practice-changing transplant study in blood cancers. October 17, Peripheral-blood stem cells versus bone marrow from unrelated donors. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia.

    Phase II study of nelarabine compound U78 in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group. Marqibo vincristine liposomal [package insert]. August Topp MS. J Clin Oncol s, suppl; abstr National Cancer Institute. December 14, ; Accessed: June 20, Smith M, Goodman B. August 30, ; Accessed: August 30, FDA approval brings first gene therapy to the United States. August 30, ; Accessed: June 20, Kymriah tisagenlecleucel [package insert]. August, Granulocyte colony-stimulating factor as an adjunct to induction chemotherapy for adult acute lymphoblastic leukemia--a randomized phase-III study.

    A randomized controlled trial of filgrastim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study Granulocyte colony-stimulating factor G-CSF, filgrastim after or during an intensive remission induction therapy for adult acute lymphoblastic leukaemia: effects, role of patient pretreatment characteristics, and costs.